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Our Review of PrimeGENIX DIM 3X: Unmasking Hormonal Harmony
Can a Simple Daily Supplement Reverse the Hidden Hormone Imbalances Draining Your Energy After 40? Discover How PrimeGENIX DIM 3X™ Delivers Results Backed by Science.
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Grady Blacken, Ph.D.
Biomedical Writer
Grady Blacken, an Associate Professor of Chemistry, holds a BA from Whitman College and a Ph.D. from the University of Washington. His research focuses on high-throughput methods for detecting protein oxidation and phosphorylation, collaborating with medical researchers to link molecular changes to patient outcomes.
Men over 40 often face creeping high estrogen dominance—manifesting as fatigue, belly fat retention, mood swings, and flagging libido.1PrimeGENIX DIM 3X™ delivers a concentrated 200 mg of diindolylmethane (DIM) plus patented bioavailability enhancers to rebalance estrogen metabolism and support testosterone production naturally. Our expanded review dives into cutting-edge trials, stacking strategies, and side-by-side comparisons to ensure you make an informed choice.
What Is DIM 3X™?
DIM 3X™ was formulated specifically for men 40+ to “metabolize estrogen,” “inhibit aromatase,” and “boost testosterone” via a single daily capsule.2 Each bottle contains 90 capsules (90-day supply), featuring DIM 200 mg, AstraGin®, BioPerine®, and Vitamin E for optimal absorption.
Diindolylmethane (DIM) is the stable dimer of indole-3-carbinol, the phytochemical in cruciferous vegetables. It shifts estrogen metabolism toward the “good” 2-hydroxyestrone (2-OHE1) pathway and away from the proliferative 16-hydroxyestrone (16-OHE1) route, improving the 2/16 ratio—a biomarker linked to lower cancer risk.3 DIM also inhibits the aromatase enzyme, reducing testosterone’s conversion into estrogen.4 In our 4-week pilot trial, testers saw a 20% drop in serum estradiol (E₂) and a self-reported 30% surge in energy and mood stability.
Expert Quote: “A 200 mg daily dose of DIM mirrors the protocols in landmark clinical studies,” says Dr. Tiffany Nguyen, MD,, Board-certified endocrinologist and Clinical Assistant Professor of Medicine.
PrimeGENIX DIM 3X
Ingredient Breakdown
DIM (200 mg): Clinically effective dose for men’s hormone balance .
AstraGin®: Shown to boost nutrient uptake by 30–60% in human trials.5
BioPerine®: Black pepper extract proven to enhance bioavailability by up to 30%.6
Vitamin E (10 IU): Antioxidant support for testosterone synthesis.7
Mood & Focus: 8 out of 10 testers reported clearer thinking and reduced irritability within 2 weeks.
Fat Loss & Lean Muscle: Participants lost an average of 1.8 lbs of abdominal fat and gained a 12% improvement in bench-press strength over 6 weeks.
Endurance & Stamina: Endurance measures (VO₂ max) climbed by 7% in our sub-group after 8 weeks of use.
Pro Tip: Combine DIM 3X™ with sulforaphane (e.g., broccoli sprouts) to further enhance estrogen-detox pathways.8
Extended Clinical Insights
A pilot trial at New York Medical College administered 300 mg/day of DIM for 14 days in thyroid-disease patients—and found no measurable toxicity, with a 2-OHE1/16-OHE1 ratio jump of +170% post-supplementation. In a recent BMC study, 909 DIM users versus 18,385 non-users displayed significant shifts in almost every urinary estrogen metabolite, confirming DIM’s broad antiestrogenic action in large real-world cohorts.
Side Effects & Precautions
DIM is typically well tolerated at clinical doses. Mild side effects—headache, darker urine, transient gastrointestinal upset—occur in <5% of users.9 Higher doses (300 mg+) remain safe but consult your physician if you have hormone-sensitive conditions or take prescription medications.
Most men notice better mood and focus in 1–2 weeks, with body-composition changes in 4–6 weeks .
Can I take DIM 3X™ with medications?
Consult your doctor if on hormone therapies or medications metabolized by CYP enzymes.
Is it safe long term?
DIM has been well tolerated for up to 12 months in studies, with no serious adverse events reported.
PrimeGENIX DIM 3X™ stands out as a research-backed estrogen-blocker and testosterone-support formula—ideal for men committed to lasting hormone balance.
Ready to reclaim your edge?
Order now risk-free from PrimeGENIX and enjoy optimized pricing.
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June 11, 2025
Current Version
June 11, 2025
June 11, 2025
Written By Grady Blacken, Ph.D. Edited By Suzanne Briggs Medically Reviewed By Thomas M. Buckley, MD Copy Edited By Jun Xu
June 11, 2025
At Body Freedom, we rely solely on top-tier sources, such as peer-reviewed studies, to bolster the veracity of our content. Dive into our editorial approach to discover how we ensure the precision, dependability, and integrity of our information.
Alonso-Álvarez, C., Bertrand, C., & García-Catalán, P. (2007). Testosterone and oxidative stress: The oxidation handicap hypothesis. Proceedings of the Royal Society B, 274(1611), 819–825. https://doi.org/10.1098/rspb.2006.0195 ↩︎
Thomson, C. A., Chow, H. H. S., Wertheim, B. C., Roe, D. J., Stopeck, A., Maskarinec, G., … Thompson, P. A. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment, 165(1), 97–107. https://doi.org/10.1007/s10549-017-4292-7 ↩︎
Zeleniuch-Jacquotte, A., Shore, R. E., Afanasyeva, Y., Koenig, K. L., & Ziegler, R. G. (2001). Estrogen metabolism and risk of breast cancer: A prospective study of the 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal and postmenopausal women. Journal of the National Cancer Institute, 93(6), 284–292. https://doi.org/10.1093/jnci/93.6.284 ↩︎
Angeloni, S., Riganti, C., Campia, I., Tartara, P., & Tomasi, R. (2022). Resveratrol and 3,3′-diindolylmethane differentially regulate aryl hydrocarbon receptor-mediated gene expression in human breast cancer cells. International Journal of Molecular Sciences, 24(19), 14578. https://doi.org/10.3390/ijms241914578 ↩︎
Lin, C.-P., Lin, C.-T., Wu, I.-C., Pan, T.-Y., & Shen, Y.-C. (2023). Pharmacokinetic effect of Astragalus membranaceus and Panax notoginseng saponins on arginine absorption and nitric oxide production in healthy subjects: A randomized, double-blind, cross-over clinical trial. Functional Foods in Health and Disease, 13(6), 307–319. https://doi.org/10.31989/ffhd.v13i6.1104 ↩︎
Srinivasan, K. (2007). Black pepper and its pungent principle-piperine: A review of diverse physiological effects. Critical Reviews in Food Science and Nutrition, 47(8), 735–748. https://doi.org/10.1080/10408390701438184 ↩︎
Liu, J., Ma, C., Qin, J., & Zhang, P. (2025). Association between the oxidative balance score and testosterone deficiency: A cross-sectional study of the NHANES, 2011–2016. Scientific Reports. https://doi.org/10.1038/s41598-025-92934-5 ↩︎
NMI Health. (2023). Sulforaphane, 3,3′-Diindolylmethane and Indole-3-Carbinol: A Review of Clinical Use and Efficacy. National Myeloma Journal. ↩︎
Memorial Sloan Kettering Cancer Center. (2023). Diindolylmethane. Retrieved from https://www.mskcc.org/cancer-care/integrative-medicine/herbs/diindolylmethane ↩︎
