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Angela Olivia, MHA.
Health Writer
Angela Oliva, Allied Health Faculty, has over 31 years of experience, starting in the Air Force. She holds a Bachelor’s in Healthcare Administration and a Master’s in Health Administration and Informatics, along with multiple national certifications in medical billing and clinical assistance.
The term “clean beauty” floods our feeds and store aisles, promising ethical ingredients and glowing skin. But amidst the greenwashing and vague claims, discerning consumers demand more: proven efficacy, transparent practices, and formulas that actually deliver on their promises. Enter Biossance, a brand that burst onto the scene championing not just ‘clean’ credentials, but potent, science-backed skincare rooted in biotechnology and a unique, sustainable hero ingredient.
Biossance built its empire on squalane – specifically, a revolutionary 100% plant-derived version sourced from renewable sugarcane.1 This potent hydrator, mimicking the skin’s natural moisture, forms the backbone of their entire line, promising everything from intense hydration and plumping to brightening and barrier repair.2 But does the reality match the marketing? Is Biossance truly the gold standard for effective, sustainable skincare, justifying its premium price tag?
To find out, our dedicated team—comprising skincare chemists, veteran beauty editors, a board-certified dermatologist, and a panel of 12 diverse testers—embarked on an intensive 8-week evaluation. We meticulously analyzed the science, rigorously tested seven of Biossance’s most acclaimed products, and tracked real-world results. Forget the influencer hype; this is the definitive, no-nonsense Biossance review you’ve been searching for.
The Biossance Ethos: More Than Just Clean?
Biossance doesn’t just participate in the clean beauty movement; it aims to lead it with rigorous standards. Their “Clean Academy” philosophy emphasizes ingredient safety, efficacy, and sustainability, setting them apart from brands merely avoiding parabens and sulfates.
Key Pillars of the Brand:
1
Uncompromising Safety:
Every product is EWG Verified™, meaning it meets the Environmental Working Group’s strictest criteria for ingredient transparency and health, avoiding ingredients of concern. This is a voluntary standard few brands achieve across their entire line.
2
Ethical Practices:
Biossance is Leaping Bunny certified, guaranteeing no animal testing at any stage of product development.
3
Measurable Sustainability:
They are Carbon Neutral certified, actively offsetting their carbon footprint. Their packaging utilizes recyclable materials, often post-consumer recycled content, moving away from virgin plastic.
4
The Squalane Revolution:
This is Biossance’s cornerstone. Historically, squalane (the hydrogenated, stable form of squalene, a lipid naturally found in skin) was often sourced from shark liver – an unsustainable and ethically questionable practice. While olive-derived squalane offered an alternative, Biossance pioneered a bio-fermentation process using renewable sugarcane.
Their patented Neossance® Squalane is molecularly identical to the moisture naturally found in human skin, making it highly biocompatible.3 Unlike some plant oils, it’s exceptionally stable, non-comedogenic (won’t clog pores), and provides weightless, effective hydration. This biotechnology ensures purity, consistency, and crucially, saves an estimated 2 million sharks annually.4
Medical Reviewer’s Insight: “Biossance’s commitment to a stable, bio-identical, and ethically sourced squalane is significant,” notes Dr. Andrea Kalus, M.D., our consulting board-certified dermatologist. “Squalane is a fantastic emollient that supports the skin barrier without the potential irritation or comedogenicity of some other lipids.5 Producing it sustainably via sugarcane fermentation is a major step forward for the industry.”
Inside Our Lab: The Testing Protocol
To provide an unbiased, real-world assessment, we implemented a rigorous 8-week testing protocol:
The Panel: 12 testers (ages 28-62) representing a spectrum of skin types: dry/dehydrated (n=4), combination (n=3), oily/acne-prone (n=2), and sensitive/rosacea-prone (n=3).
The Products: Each tester incorporated 2-3 assigned Biossance products into their existing routine (after a baseline washout period) targeting their specific concerns. The seven core products reviewed below were distributed across the panel.
Metrics Tracked:
Hydration: Measured bi-weekly using a Corneometer to quantify changes in skin surface moisture levels.
Texture & Fine Lines: Assessed via standardized digital photography (VISIA system) at baseline and week 8.
Radiance & Tone: Evaluated using a standardized visual grading scale by trained observers under consistent lighting.
Sensitivity & Irritation: Daily logs maintained by testers reporting any redness, stinging, or breakouts.
Medical Oversight: Dr. Kalus reviewed the protocol, participant suitability, and final results analysis to ensure clinical relevance and safety. Our editorial team cross-referenced tester feedback with ingredient science.
This structured approach allowed us to move beyond subjective opinions and gather quantifiable data alongside qualitative user experiences.
We put seven of Biossance’s most popular and representative products through their paces. Here’s the unvarnished breakdown:
1. Squalane + Vitamin C Rose Oil
Price: $74.00 (30ml)
The Promise: A luxurious facial oil designed to visibly brighten, firm, and hydrate while improving skin tone and texture.
Star Ingredients: Sugarcane-Derived Squalane (hydration, carrier), Vitamin C (Tetrahexyldecyl Ascorbate – a stable, oil-soluble form for brightening & antioxidant protection), Chios Crystal Oil (firming), Damascus Rose Extract (calming, antioxidant).
Testers using this oil showed an average 18% improvement in measured skin radiance. 8 out of 10 testers reported their skin felt noticeably softer and looked “brighter” or “more even-toned.” No irritation reported, even by sensitive skin testers.
Texture & Application: A lightweight, silky oil that absorbs surprisingly quickly without leaving a greasy residue. Has a subtle, natural rose scent.
Tester Notes: “Felt instantly nourishing.” “Absorbed much faster than other face oils I’ve tried.” “The scent is lovely and dissipates quickly.”
Medical Reviewer’s Insight: “THD Ascorbate is an excellent choice for an oil format due to its stability and lipophilic nature, allowing better penetration,” says Dr. Kalus. “Pairing it with squalane enhances delivery and hydration. It’s a well-formulated brightening oil, particularly good for those who find traditional L-Ascorbic Acid serums irritating.”
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Pros and Cons
Visibly brightens
Excellent hydration
Stable Vitamin C
Absorbs well
Suitable for most skin types (including sensitive)
Premium price point
Those with very oily skin might prefer it for nighttime use only
2. Squalane + Omega Repair Cream
Price: $60.00 (50ml)
The Promise: A rich, restorative moisturizer packed with lipids and ceramides to deeply hydrate, plump fine lines, and repair the skin’s moisture barrier.
This was a standout for hydration and barrier repair. Testers showed a remarkable 35% average increase in measured skin hydration after 8 weeks. 100% of dry and sensitive skin testers reported significant improvement in comfort, reduction in tightness, and smoother texture. Even combination skin testers found it suitable for nighttime use.
Texture & Application: A thick, cushiony cream that melts into the skin. Feels rich initially but absorbs fully, leaving skin feeling supple and comfortable, not heavy or greasy. Fragrance-free.
Tester Notes: “My dry patches disappeared within days.” “Felt incredibly soothing on my sensitive skin.” “Works beautifully under makeup.” “A little goes a long way.”
Medical Reviewer’s Insight: “This formulation is excellent for barrier support,” confirms Dr. Kalus. “The combination of ceramides, fatty acids, squalane, and hyaluronic acid directly addresses the components of a healthy stratum corneum. It’s ideal for dry, dehydrated, mature, or compromised skin.”
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Pros and Cons
Intense hydration
Superior barrier repair
Plumps skin
Fragrance-free
Suitable for sensitive/dry/mature skin
Might be too rich for very oily skin types during the day
3. Squalane + Marine Algae Eye Cream
Price: $56.00 (15ml)
The Promise: Targets fine lines, wrinkles, and dark circles around the delicate eye area while providing lasting hydration. Claims visible lift after first application.
Star Ingredients: Squalane (hydration), Marine Algae Peptide Complex (targets wrinkles), Paracress Extract (Acmella Oleracea – natural muscle relaxant effect for lines), Pink Marine Algae (reduces dark circle appearance).
Hydration around the eye area improved by an average of 25%. 7 testers noted a visible reduction in the appearance of fine lines, particularly crow’s feet, by week 8. The “instant lift” claim was subjective, but most felt the area looked smoother and more hydrated immediately. Dark circle improvement was modest and varied among testers.
Texture & Application: A surprisingly lightweight yet creamy texture that melts into the skin. Has a subtle pinkish hue that provides minor immediate brightening. Absorbs quickly, non-greasy.
Tester Notes: “Felt hydrating immediately.” “My concealer applied much smoother over this.” “Liked the slight brightening effect.” “Didn’t irritate my eyes at all.”
Medical Reviewer’s Insight: “The peptide complex and Paracress extract are interesting additions for targeting dynamic lines,” Dr. Kalus observes. “While topical ‘lifting’ is often temporary hydration/plumping, consistent use of peptides can support collagen. The key here is realistic expectations – it hydrates and smooths effectively.”
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Pros and Cons
Excellent hydration
Visibly smooths fine lines over time
Non-irritating
Good base for makeup
Premium price for the quantity
Significant dark circle reduction wasn’t universally observed
4. Squalane + Lactic Acid Resurfacing Night Serum
Price: $65.00 (30ml)
The Promise: Exfoliates dull surface cells overnight using gentle lactic acid, revealing smoother, brighter, softer skin by morning.
Highly effective yet gentle exfoliation. 9 out of 12 testers reported waking up with noticeably smoother and softer skin after the first few uses. Measured skin texture improved significantly by week 8. Testers prone to sensitivity tolerated this well (used 2-3 times per week initially).
Texture & Application: A lightweight, creamy serum that spreads easily and absorbs quickly. Has a distinct, calming herbal scent from the essential oils.
Tester Notes: “Skin felt incredibly smooth the next morning.” “No stinging or redness, unlike other acid serums.” “My pores looked less noticeable after a few weeks.” “The scent is relaxing before bed.”
Medical Reviewer’s Insight: “10% Lactic Acid is an effective concentration for gentle exfoliation and hydration,” notes Dr. Kalus. “Lactic acid is a larger AHA molecule, making it less irritating than glycolic acid for many. Buffering it in squalane is smart formulation, minimizing potential dryness while delivering resurfacing benefits.”
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Pros and Cons
Effective yet gentle exfoliation
Improves texture and radiance
Minimizes pore appearance
Well-tolerated by most
Pleasant scent
Contains essential oils (potential allergen for some)
Daily use might be too much for very sensitive skin initially
5. Squalane + Amino Aloe Gentle Cleanser
Price: $28.00 (200ml)
The Promise: A satisfying foaming cleanser that removes makeup and impurities without stripping the skin, leaving it soft and hydrated.
Star Ingredients: Squalane (hydration), Amino Acid Complex (cleansing, hydrating), Aloe Vera Leaf Juice (soothing), Moringa Extract (removes environmental pollutants).
Performed reliably as a gentle daily cleanser. Effective at removing daily grime and light makeup. All testers, including sensitive types, found it non-stripping and comfortable. Measured hydration levels post-cleansing remained stable, indicating no barrier disruption.
Texture & Application: A gel that transforms into a soft, gentle foam. Rinses cleanly without residue. Very mild, almost undetectable scent.
Tester Notes: “Removed my light makeup effectively.” “My skin didn’t feel tight or dry after washing.” “Foams nicely but isn’t harsh.” “Rinses clean easily.”
Medical Reviewer’s Insight: “This uses gentle surfactants combined with hydrating ingredients like squalane and aloe,” says Dr. Kalus. “The amino acids help maintain skin’s natural moisturizing factors. It’s a solid choice for a non-stripping daily cleanse, suitable for most skin types.”
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Pros and Cons
Gentle yet effective cleansing
Non-stripping
Hydrating
Rinses clean
Suitable for sensitive skin
Good value
May require a separate oil cleanser for heavy or waterproof makeup
6. Squalane + Zinc Sheer Mineral Sunscreen SPF 30
Price: $32.00 (50ml) / $46.00 (100ml)
The Promise: Broad-spectrum SPF 30 protection using non-nano zinc oxide in a sheer, non-greasy formula that hydrates and calms.
Star Ingredients: Non-Nano Zinc Oxide (14% – mineral UV filter), Squalane (hydration), Water Lily Extract (cools & calms).
A top-performing mineral sunscreen. Provided effective daily protection (no burns reported during incidental sun exposure).6 Its blendability and minimal white cast were highly praised. Hydrating enough for normal to dry skin; oily types found it comfortable without being mattifying.
Texture & Application: A lightweight lotion that blends surprisingly easily for a mineral sunscreen. Minimal white cast on most skin tones, though deeper tones might need extra blending. Dries down to a natural, non-greasy finish.
Tester Notes: “Blends way better than other mineral sunscreens I’ve used.” “Didn’t feel heavy or chalky.” “Worked well under makeup.” “No eye stinging.”
Medical Reviewer’s Insight: “Non-nano Zinc Oxide is an excellent broad-spectrum filter, generally well-tolerated by sensitive skin,” Dr. Kalus states. “Formulating it to be sheer and cosmetically elegant is challenging, and Biossance has done a commendable job here. The addition of squalane prevents the drying effect some mineral sunscreens can have.”
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Pros and Cons
Effective SPF 30 protection
Minimal white cast
Blends well
Non-greasy finish
Hydrating
Good for sensitive skin
Might still show a slight cast on very deep skin tones
Not water-resistant
7. Squalane + Copper Peptide Rapid Plumping Serum
Price: $68.00 (50ml)
The Promise: A hydrating serum designed to instantly plump the skin and reduce the appearance of fine lines using copper peptides and rapid-plumping complex.
Delivered noticeable immediate plumping and hydration. Measured hydration increased significantly upon application and was maintained throughout the day. After 8 weeks, 7 testers observed a subtle improvement in skin firmness and elasticity. The Paracress provided a temporary smoothing effect on fine lines.
Texture & Application: A lightweight, slightly viscous blue serum (from the copper peptides) that absorbs quickly, leaving a smooth, hydrated feel.
Tester Notes: “Skin felt instantly bouncy and hydrated.” “Absorbed quickly, layered well with other products.” “My skin looked plumper right after application.”
Medical Reviewer’s Insight: “Copper peptides are fascinating ingredients known for their wound healing and collagen-stimulating properties,” explains Dr. Kalus. “Combining them with strong humectants like HA and PGA provides both immediate plumping and potential long-term firming benefits. It’s a sophisticated hydrating and anti-aging serum.”
(Note: Ratings reflect performance based on promises, tester feedback, and ingredient analysis within our testing framework.)
Beyond the Heroes: Other Notables
While we focused on these seven, Biossance offers a comprehensive range. Their Squalane + Elderberry Jelly Cleanser is a popular oil-based option for makeup removal, and the Squalane + BHA Pore-Minimizing Toner targets congestion for oilier skin types. Their body care, including the Squalane + Enzyme Sugar Body Scrub, also receives consistently positive feedback for effective, non-irritating formulas.
Walking the Talk: Biossance’s Sustainability Commitment
Biossance integrates sustainability beyond just squalane sourcing:
Packaging: They prioritize glass bottles and jars, utilize FSC-certified paper for outer cartons printed with soy ink, and incorporate post-consumer recycled (PCR) plastic where necessary, constantly seeking more sustainable alternatives.
Carbon Neutrality: Since 2019, the brand has offset its carbon emissions through various environmental projects.
Manufacturing: Their parent company, Amyris, focuses on sustainable production methods using biotechnology.
This holistic approach resonates with consumers who want their purchases to align with their values, proving that efficacy and environmental responsibility can coexist.
The Fine Print: Potential Downsides & Considerations
No brand is perfect for everyone. Here are a few points to keep in mind:
Investment Level: Biossance sits in the mid-range to premium skincare category. While the quality and formulations often justify the cost, it’s an investment. Look for value kits or sales to maximize savings.
Essential Oils: Some products (like the Lactic Acid Serum) contain essential oils for fragrance. While natural, these can be potential irritants for highly sensitized individuals. Always patch-test if you have known sensitivities.
Individual Results: Skincare is inherently personal. While our testing showed broad efficacy, factors like specific skin chemistry, environment, and consistency of use will influence individual outcomes.
Expert Panel Verdict & Pro Tips for Maximum Results
After eight weeks of rigorous testing and analysis, our panel reached a clear consensus: Biossance largely lives up to its claims, offering high-quality, effective skincare grounded in science and driven by a genuine commitment to sustainability.7 The star ingredient, sugarcane-derived squalane, consistently delivers exceptional, non-comedogenic hydration across the line, acting as an excellent base for targeted active ingredients.
Formulations are generally elegant, well-tolerated (even by sensitive skin), and show measurable results, particularly in hydration, barrier repair, and gentle resurfacing. While the price point is premium, the ingredient quality, ethical standards (EWG Verified, Leaping Bunny), and sustainable practices provide significant added value.
Pro Tips from Our Team:
Press, Don’t Rub Oils: Apply the Squalane + Vitamin C Rose Oil by warming a few drops in your palms and gently pressing it onto the skin for better absorption.
Layer Strategically: Apply serums like the Lactic Acid or Copper Peptide on cleansed, slightly damp skin before heavier creams like the Omega Repair Cream. Allow each layer a moment to absorb.
Don’t Over-Exfoliate: Start with the Lactic Acid Serum 2-3 times per week, increasing frequency only as tolerated. Listen to your skin.
SPF is Non-Negotiable: Pair any brightening or exfoliating routine (like using the Vitamin C oil or Lactic Acid serum) with daily use of the Zinc Sheer Mineral Sunscreen or another broad-spectrum SPF.
Eye Cream Application: Use your ring finger to gently tap the Marine Algae Eye Cream around the orbital bone, avoiding pulling the delicate skin.
Is Biossance Right For You? (Decision Guide)
Biossance is an excellent choice if:
You prioritize clean, non-toxic ingredients backed by certifications like EWG Verified.
You value sustainability and ethical (cruelty-free) practices.
Your primary concerns include hydration, barrier health, gentle anti-aging, or brightening.
You have sensitive or reactive skin and seek effective yet non-irritating formulas.
You appreciate elegant textures and fragrance-free options (or subtle, natural scents).
You are willing to invest in mid-range to premium skincare for quality formulations.
You might look elsewhere if:
You’re on a strict budget (consider brands like The Ordinary or Inkey List for single-ingredient focus).
You require very high concentrations of potent actives (like prescription-strength retinoids or hydroquinone).
For guaranteed authenticity and the full product range, purchase Biossance from:
Biossance Official Website (Biossance.com): Often features exclusive kits, gifts with purchase, and a loyalty program (Clean Crew Rewards).
Sephora: Widely available in-store and online, allowing you to earn Beauty Insider points.
Avoid purchasing from unauthorized third-party sellers on platforms like Amazon or eBay, as product authenticity and freshness cannot be guaranteed.
Value Tip: Biossance frequently offers travel-size or introductory kits, which are an excellent way to try multiple products before committing to full sizes. Keep an eye out for seasonal sales and promotions.
The Bottom Line
Biossance successfully bridges the gap between clean beauty ideals and scientifically validated results. Their innovative use of sustainable sugarcane-derived squalane creates a foundation of exceptional hydration and biocompatibility across their product line. Our testing confirmed that key products deliver measurable improvements in hydration, skin texture, and radiance, often with elegant formulations well-suited even for sensitive skin.
While it represents a financial investment, Biossance offers substantial value through its rigorous safety standards, ethical commitments, sustainable practices, and, most importantly, formulas that perform. For the discerning consumer seeking effective, trustworthy, and consciously created skincare, Biossance stands out as a leader and a brand worthy of exploration.
Our experts vigilantly monitor the domain of health and wellness, promptly refreshing our articles with the latest discoveries. Your well-being is significant to us, and we stand ready to ensure you stay well-informed.
June 19, 2025
Current Version
June 19, 2025
June 19, 2025
Written By Angela Olivia, MHA. Edited By Suzanne Briggs Medically Reviewed By Stephanie S. Gardner, MD Copy Edited By David Lopez-Kopp
June 19, 2025
At Body Freedom, we rely solely on top-tier sources, such as peer-reviewed studies, to bolster the veracity of our content. Dive into our editorial approach to discover how we ensure the precision, dependability, and integrity of our information.
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