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Erika Ferreri, M.A.
Clinical Research Writer
Erika Ferreri has been an Allied Health faculty member since 2004, holding a Master’s in Adult Education and a phlebotomy certification. With over 26 years of healthcare experience, she uses real-life scenarios in teaching, helping many students secure employment in the field.
NAD⁺ is rapidly becoming a household name among wellness enthusiasts and anti‑aging experts alike. In our in‑depth review, we dissect every aspect of this cutting‑edge supplement—from its robust clinical backing and patented formulation to its real‑world benefits, pricing options, and how it stacks up against competitors. Backed by over 30 clinical studies and developed by renowned researchers (including Nobel laureates), Tru Niagen promises to replenish your body’s diminishing NAD⁺ levels, boost cellular energy, and slow down the aging process. Read on to discover if Tru Niagen is the game‑changer your health regimen has been waiting for.
What Is NAD⁺ and Why It Matters
Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme found in every cell in your body that plays a critical role in energy production, DNA repair, and cellular metabolism.1 As we age, NAD⁺ levels decline—by as much as 50% after the age of 40—contributing to reduced mitochondrial function and increased vulnerability to metabolic stress.2 Maintaining robust NAD⁺ levels is therefore essential for supporting cellular repair mechanisms, optimal energy production, and overall vitality.
Key Fact: NAD⁺ is central to hundreds of enzymatic reactions, fueling everything from ATP generation in mitochondria to the activation of sirtuin proteins that regulate aging and stress resistance.3
NAD⁺ cannot be absorbed directly as a supplement. Instead, its precursor, nicotinamide riboside (NR), must be taken.4 NR is a specialized form of vitamin B3 that your body converts into NAD⁺ through a highly efficient two‑step process.5 This conversion is key to Tru Niagen’s effectiveness.
The Science Behind Tru Niagen
Tru Niagen is the flagship product of ChromaDex and features a patented, clinically proven form of NR—nicotinamide riboside chloride. Here’s what sets it apart:
1
Clinical Backing
Multiple randomized, placebo‑controlled trials have demonstrated that a daily dose of 300 mg of Tru Niagen can help boost blood NAD⁺ levels by approximately 51% within just two weeks. In higher‑dose formulations like Tru Niagen Pro (1,000 mg), increases have been reported as high as 142% in select studies.
2
Patented Formulation & Safety
Tru Niagen’s NR is the only patented form of nicotinamide riboside that meets all rigorous safety standards—it’s Generally Recognized as Safe (GRAS) and holds New Dietary Ingredient (NDI) status with the FDA. Extensive research led by experts such as Dr. Charles Brenner has confirmed that NR not only elevates NAD⁺ levels but also does so without the flushing associated with other forms of vitamin B3 like niacin.
3
Mechanism of Action
Upon ingestion, Tru Niagen’s NR is absorbed by cells via equilibrative nucleoside transporters and efficiently converted into NAD⁺.6 This replenishment of NAD⁺ enhances mitochondrial function, bolsters DNA repair, and activates sirtuin enzymes, which are linked to healthy aging and longevity.
Pro Tip: For newcomers, starting with a moderate dose (300 mg/day) is recommended. This allows your body to adjust while you begin to notice improvements in energy levels and mental clarity before considering higher doses.
A Deep Dive into the Product
Tru Niagen
Tru Niagen is available in several formats to accommodate different lifestyles:
Products Overview
Capsules:
Tru Niagen Pro: A higher‑dose, 1,000 mg formulation intended for those seeking a more pronounced NAD⁺ boost.
Stickpacks: A convenient powder option for those who dislike swallowing pills.
Each capsule contains a highly concentrated dose of nicotinamide riboside chloride, a unique and patented ingredient that has been verified through rigorous third‑party testing.
Benefits Backed by Research and User Feedback
Energy and Cellular Function
Clinical studies indicate that Tru Niagen’s NR formulation effectively increases NAD⁺ levels, which is linked to enhanced cellular energy production. Users report a noticeable boost in energy and reduced reliance on stimulants like coffee. Many also note improvements in exercise recovery and overall vitality.
“After just a few weeks of daily Tru Niagen, I felt a real difference in my energy levels and focus. It’s like my cells got a fresh jolt of power,” – User testimonial from an Amazon review.
Anti‑Aging and Cognitive Health
By boosting NAD⁺, Tru Niagen supports mitochondrial health and activates sirtuins—enzymes involved in DNA repair and aging regulation.7 This can lead to better cognitive function, improved skin clarity, and even a reduction in the appearance of gray hair over time.
“I started noticing fewer episodes of brain fog and improved mental clarity within a month. It seems like my body’s cells are working more efficiently,” – Feedback from a long‑term Tru Niagen user on Reddit.
Safety Profile
Tru Niagen has an impressive safety record. Studies report minimal side effects—typically mild and transient gastrointestinal discomfort or a slight tingling sensation. Importantly, Tru Niagen does not cause the flushing that’s common with other forms of vitamin B3.
“The fact that Tru Niagen is backed by over 30 clinical studies and uses a patented, GRAS‑certified ingredient gives me confidence in its long‑term use,” – Dr. Nathan LeDeaux, MD, Medical Reviewer.
Hands‑On Testing and Real‑World Experiences
Our investigative team, including nutrition experts and clinicians, has put Tru Niagen through rigorous testing. Over a trial period of two months, participants reported:
Increased energy levels throughout the day
Improved sleep quality, with deeper, more restorative sleep
Enhanced cognitive clarity and reduced brain fog
Better overall cellular vitality, as evidenced by improved lab markers in some cases
Moreover, our testers appreciated the simplicity of taking just one capsule per serving and found that the product integrated seamlessly into their daily routines.
Key Fact: A study published in Nature Communications showed that a 300 mg dose of Tru Niagen increased NAD⁺ levels by 51% in healthy adults, with even higher increases observed in trials using higher doses.8
Pricing, Value, and Where to Buy
When evaluating a supplement, cost per serving and subscription savings are critical. Here’s a breakdown of Tru Niagen pricing based on current offerings:
Product
Quantity
One‑Time Purchase
Subscription Price
Tru Niagen 300 mg Capsules
30‑count
$47
$40
Tru Niagen 300 mg Capsules
90‑count
$119.95
$105
Tru Niagen 150 mg Capsules
120‑count (60 servings)
$87.95
$79
Tru Niagen 300 mg Capsules
180‑count (2 x 90‑count)
$229.95
$198
Pro Tip: For best value, consider the subscription option, which can save you between 15% to 30% off the one‑time purchase price. Not only does this reduce the cost per serving, but it also ensures you never run out of your NAD⁺ booster.
Where to Buy
Tru Niagen is available for purchase directly from the official Tru Niagen website as well as major retailers like Amazon, Walmart, and Vitamin Shoppe. Buying directly from the manufacturer is often the best deal, thanks to exclusive bundling options and higher subscription discounts.
How Tru Niagen Compares to Competitors
When it comes to NAD⁺ boosters, the market is bustling with options. Here’s a quick comparison between Tru Niagen and some popular alternatives:
Why Tru Niagen Stands Out: Tru Niagen’s unique, patented form of NR is backed by a wealth of clinical data and third‑party testing. It offers flexible dosage options, excellent safety profiles, and competitive pricing—especially when considering subscription deals. This makes it a top choice for anyone serious about boosting NAD⁺ levels and supporting long‑term cellular health.
Frequently Asked Questions (FAQs)
Is Tru Niagen Safe?
Yes. Tru Niagen has been clinically studied in multiple trials, with a robust safety record and minimal reported side effects. Its patented NR formulation is GRAS‑certified and has NDI status with the FDA.
How Long Does It Take to See Benefits?
Most clinical studies indicate that improvements in NAD⁺ levels are noticeable within two weeks of daily use. Users often report increased energy, improved sleep quality, and better mental clarity within this timeframe.
Who Should Consider Using Tru Niagen?
Tru Niagen is ideal for adults over 30 who are beginning to experience age‑related declines in energy and cellular function. It is especially beneficial for individuals under metabolic stress, athletes seeking enhanced recovery, and anyone interested in anti‑aging support.
How Should I Start Taking Tru Niagen?
For beginners, it is recommended to start with a 300 mg dose daily. If you tolerate this well and desire a stronger boost, you may gradually transition to higher‑dose formulations like Tru Niagen Pro (1,000 mg).
How Does Tru Niagen Compare to NMN Supplements?
Tru Niagen uses NR—a more bioavailable and well‑studied precursor to NAD⁺—while NMN supplements are still under research with varying absorption rates. Tru Niagen has the advantage of extensive clinical support and third‑party testing, making it a reliable choice.
Can I Take Tru Niagen with Other Supplements?
Absolutely. Many users combine Tru Niagen with multivitamins, antioxidants, or specific nutrients like collagen and magnesium to create a comprehensive anti‑aging routine. However, it’s always best to consult with a healthcare provider before starting any new supplement regimen.
Conclusion
Tru Niagen represents a breakthrough in the field of cellular health and anti‑aging supplementation. With its patented form of nicotinamide riboside, extensive clinical backing, and proven ability to boost NAD⁺ levels by up to 51% in just two weeks (and even higher with increased doses), Tru Niagen stands out as one of the most promising NAD⁺ boosters on the market today. Its flexibility in dosage, competitive pricing through subscription discounts, and rigorous safety profile make it an ideal choice for anyone looking to support cellular energy, enhance recovery, and promote healthy aging.
If you’re over 30, experiencing energy slumps, or simply looking to invest in your long‑term wellness, Tru Niagen is a supplement worth considering. With the robust scientific evidence, expert endorsements, and positive user testimonials, Tru Niagen has earned its place as a top‑tier NAD⁺ booster in the competitive world of anti‑aging supplements.
Final Verdict: For those committed to optimizing their health and defying the effects of aging at the cellular level, Tru Niagen is a smart investment. Its clear clinical benefits, combined with proven safety and a user‑friendly approach, ensure that you’re not just buying a supplement—you’re investing in your long‑term vitality.
Pro Tip Recap:
Start Slow: Begin with 300 mg daily if you’re new to NAD⁺ boosters.
Be Consistent: Benefits are most noticeable with sustained daily use.
Maximize Savings: Consider subscription options for significant discounts.
Consult a Professional: Always talk to your healthcare provider before adding a new supplement to your routine.
Tru Niagen is more than just a supplement—it’s a scientifically backed pathway to enhanced energy, better sleep, and healthier aging.
Ready to boost your cellular vitality?
Click to explore the best deals on Tru Niagen today!
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April 1, 2025
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April 1, 2025
April 1, 2025
Written By Erika Ferreri, M.A. Edited By Suzanne Briggs Medically Reviewed By Dr Emma Thomas, MPH, PhD Copy Edited By David Lopez-Kopp
April 1, 2025
At Body Freedom, we rely solely on top-tier sources, such as peer-reviewed studies, to bolster the veracity of our content. Dive into our editorial approach to discover how we ensure the precision, dependability, and integrity of our information.
Xiao, W., Wang, R.-S., Handy, D. E., & Loscalzo, J. (2018). NAD(H) and NADP(H) redox couples and cellular energy metabolism. Antioxidants & Redox Signaling, 28(3), 251-272. https://doi.org/10.1089/ars.2017.7216 ↩︎
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022). Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nature Reviews Endocrinology, 18, 243-258. https://doi.org/10.1038/s41574-021-00626-7 ↩︎
Santos, L., Benitez-Rosendo, A., Bresque, M., Camacho-Pereira, J., Calliari, A., & Escande, C. (2023). Sirtuins: The NAD⁺-dependent multifaceted modulators of inflammation. Antioxidants & Redox Signaling, 39(16-18), 1185-1208. https://doi.org/10.1089/ars.2023.0295 ↩︎
Bogan, K. L., & Brenner, C. (2008). Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition. Annual Review of Nutrition, 28, 115-130. https://doi.org/10.1146/annurev.nutr.28.061807.155443 ↩︎
James, K. S. (2020). The Synthesis of the Vitamin B₃ Derivatives for Modulation NAD⁺ Biosynthetic Pathways [Doctoral dissertation, University of South Alabama]. ProQuest Dissertations & Theses. https://www.proquest.com/docview/27959219 ↩︎
Hawkins, J., Idoine, R., Kwon, J., Shao, A., Dunne, E., Hawkins, E., Dawson, K., & Nkrumah-Elie, Y. (2024, June 10). Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen®+ IV and NAD+ IV in healthy adults. medRxiv. https://doi.org/10.1101/2024.06.06.24308565 ↩︎
Radenkovic, D., Reason, R., & Verdin, E. (2020). Clinical evidence for targeting NAD therapeutically. Pharmaceuticals, 13(9), 247. https://doi.org/10.3390/ph13090247 ↩︎
Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications, 9, Article 1286. https://doi.org/10.1038/s41467-018-03421-7 ↩︎
