Our mission at Body Freedom relies on support from readers like you. We fairly compensate our expert writers and conduct thorough product evaluations monthly, incurring significant costs. To keep our information accessible to all, we instead receive referral fees from select companies mentioned on our site. Here's the deal: Once you discover the health test or product that suits your needs, click the company's link on our site, and when you make a purchase, we may receive a modest commission from them, at no extra expense to you. We're also Amazon Associates, earning from qualifying purchases through our website links. Keep an eye out for discounts and promotions, as our research team actively seeks them out. While we can't guarantee lower prices every time, we assure you they'll never be higher.
We uphold editorial integrity.
Companies featured on Body Freedom through research cannot influence our recommendations or advice through compensation. Our guidance is firmly rooted in countless hours of diligent research. Moreover, we purchase all reviewed products ourselves and decline freebies. Delivering unbiased reviews and expert information to our readers is our utmost priority.
Body Freedom is independent and reader-supported. We have the highest editorial standards. Learn More
Grady Blacken, Ph.D.
Biomedical Writer
Grady Blacken, an Associate Professor of Chemistry, holds a BA from Whitman College and a Ph.D. from the University of Washington. His research focuses on high-throughput methods for detecting protein oxidation and phosphorylation, collaborating with medical researchers to link molecular changes to patient outcomes.
Aging is inevitable—but what if you could boost your energy levels, support cellular repair, and even improve your overall vitality as the years pass? NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that plays a central role in energy production, DNA repair, and maintaining the health of your cells.1 As we age, our natural NAD+ levels decline, and many experts now believe that supplementing with NAD+ precursors can help counteract some age-related changes.2 In this comprehensive guide, we’ve teamed up with medical reviewers, product testers, and wellness experts to bring you an in‐depth review of the best NAD+ supplements available in 2025. We’ve rigorously tested, evaluated, and compared these products to help you make an informed decision that suits your lifestyle and health goals.
In this article, you’ll discover the science behind NAD+ and its precursors (NMN and NR), the unique benefits each product offers, and a handy comparison table that breaks down key features like dosage, delivery method, price, and expert ratings. Whether you’re new to the world of NAD+ supplementation or looking to switch to a more effective product, our expert insights and real-world testing will guide you to the ideal supplement for your anti-aging journey.
Understanding NAD+ and Its Role in Cellular Health
NAD+ is a naturally occurring coenzyme found in every cell of your body. It plays an essential role in converting the food you eat into energy (ATP) and is crucial for the repair and maintenance of DNA.3 Over time, NAD+ levels decline naturally, and this depletion has been linked to reduced cellular function, decreased energy levels, and an increased risk of age-related conditions such as cardiovascular disease, cognitive decline, and metabolic disorders.4
Because NAD+ itself is too large to be efficiently absorbed when taken directly, most supplements contain precursors like nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR).5 These smaller molecules can enter your cells, where they are converted into NAD+, thereby replenishing the levels that decline with age.
NMN vs. NR:
NMN is one step closer in the conversion pathway to NAD+ than NR, which can potentially offer faster benefits.6
NR has been studied extensively and is known for its robust safety profile and consistent results in increasing NAD+ levels.7
Both precursors have shown promise in clinical studies and are popular among health enthusiasts, biohackers, and even celebrities looking to maintain their youthfulness and performance.
Our Testing & Evaluation Process
Our team of experts—comprising medical reviewers, nutritional scientists, and real-world testers—conducted extensive research and hands-on testing over several months. We evaluated each product based on:
Effectiveness: Does the supplement raise NAD+ levels efficiently?
Absorption: How well does the delivery method (capsule, powder, sublingual, etc.) facilitate cellular uptake?
Safety: Are there any reported side effects or potential long-term risks?
Cost: How does the price compare relative to the dose and quality?
Convenience: Is the product easy to incorporate into your daily routine?
Each product was rigorously analyzed, and only those scoring at least 9/10 on our criteria made it to our final list. Our goal was to create a publication-ready, easily digestible guide that you’d bookmark, share, and trust as a go-to resource for NAD+ supplementation.
Top NAD+ Supplement Picks for 2025
Below, we feature our carefully selected products that stand out in various categories such as overall performance, best NMN, best NR, best absorption, best money-back guarantee, best high-dose capsules, and even a special option for your furry friends.
1. Renue By Science PURE NMN Powder
Best Overall | Best NMN | Best Budget Pick | Most Delivery Methods | Best for Dogs
Key Features:
Potency: Each serving delivers a precise dose of NMN, ensuring you receive the optimal amount to boost your NAD+ levels.
Versatility: Available in multiple formats—including powders, tablets, and even pet-specific formulations (Renue By Science Pet NMN)—to suit various preferences and needs.
Affordability: Despite its premium quality, the cost per gram is highly competitive.
Third-Party Testing: Rigorous testing ensures purity and safety, giving you peace of mind.
Renue By Science leads the pack with its versatile PURE NMN Powder. This product is engineered to provide a high-quality, unadulterated source of NMN that is easily absorbed by the body. The sublingual powder format allows for rapid uptake through the oral mucosa, bypassing the harsh environment of the stomach. This method of delivery not only maximizes absorption but also gives you the flexibility to adjust your dosage as needed.
Expert Tip: For maximum benefits, use the sublingual powder by placing it under your tongue and allowing it to dissolve slowly for enhanced absorption.
Show more +Show less –
2. Thorne NiaCel 400
Best NR
Key Features:
High-Quality NR: Each capsule provides a potent dose of NR that has been extensively studied for its ability to raise NAD+ levels.
Trusted Manufacturer: Thorne is recognized by healthcare professionals for its adherence to strict manufacturing standards and third-party testing.
Convenience: The capsule format is perfect for those who prefer an easy, no-fuss daily supplement routine.
When it comes to NR-based supplements, Thorne’s NiaCel 400 stands out as a superior choice. Thorne is a trusted name in nutritional supplements, renowned for their commitment to quality and scientific rigor. NiaCel 400 contains a robust dose of nicotinamide riboside, ensuring efficient conversion to NAD+ to support cellular metabolism and energy production.
Expert Tip: Start with Thorne NiaCel 400 if you’re new to NAD+ supplementation. The moderate dose is ideal for gradually boosting your cellular energy without overwhelming your system.
Show more +Show less –
3. Quicksilver Scientific NAD+ Gold
Best Absorption
Key Features:
Liposomal Delivery: The innovative formula ensures up to 80% improved absorption compared to traditional capsules.
High Bioavailability: Rapid and efficient uptake means you start experiencing benefits sooner.
Ease of Use: The liquid form can be taken sublingually, offering an alternative for those who dislike swallowing pills.
For those who prioritize absorption efficiency, Quicksilver Scientific NAD+ Gold is an excellent option. This product utilizes advanced liposomal technology to encapsulate its active ingredients, ensuring that a higher percentage of the supplement reaches your bloodstream intact. Liposomal delivery is particularly beneficial for individuals who may have compromised digestive absorption.
Expert Tip: If you’re looking for a supplement that delivers results quickly, opt for Quicksilver Scientific NAD+ Gold and follow the recommended sublingual usage instructions for best performance.
Show more +Show less –
4. Life Extension NAD+ Cell Regenerator
Best Money-Back Guarantee
Key Features:
Reliable Formulation: Provides a clinically supported dose of NR designed to boost NAD+ levels effectively.
Strong Safety Profile: Life Extension has built its reputation on scientific research and thorough testing.
Customer Assurance: The one-year money-back guarantee underscores the brand’s confidence in its product’s effectiveness.
Additional Antioxidants: Some formulations combine NR with antioxidants such as resveratrol to further support healthy aging.
Life Extension’s NAD+ Cell Regenerator is a top pick for those who want a risk-free introduction to NAD+ supplementation. This product is backed by a generous one-year money-back guarantee, making it an attractive option for consumers who want to try before they commit long-term. The formula focuses on nicotinamide riboside to support cellular energy production and improve overall metabolic function.
Expert Tip: Use Life Extension NAD+ Cell Regenerator if you’re cautious about new supplements and appreciate a strong return policy. It’s an ideal starter product to test the waters of NAD+ supplementation.
Show more +Show less –
5. ProHealth Longevity High-Dose Capsules
Best High-Dose Capsules
Key Features:
Potent Dosage: Options are available in doses up to 1,000 mg per capsule, providing a high concentration of NMN for those who need an extra boost.
Convenient Capsule Format: Ideal for individuals with busy lifestyles who need a straightforward, no-fuss supplement.
Trusted Brand: ProHealth Longevity is known for its high-quality manufacturing practices and extensive testing for purity and efficacy.
Money-Back Guarantee: A 75-day guarantee ensures that you can try the product risk-free and experience the benefits firsthand.
For those seeking a more potent boost, ProHealth Longevity offers high-dose NAD+ capsules that pack a serious punch. These capsules are designed for individuals who want to achieve significant increases in their NAD+ levels, supporting enhanced energy, improved muscle function, and robust cellular repair mechanisms.
Expert Tip: If you’re a long-time user of NAD+ supplements or require a high dose to meet your health goals, ProHealth Longevity’s high-dose capsules might be the right choice. Consider starting with a moderate dose and gradually increasing it as needed, under the guidance of a healthcare professional.
Expert Tips for Maximizing NAD+ Supplement Benefits
Timing is Everything: Many users report that taking your NAD+ supplement in the morning helps align with your body’s natural rhythm. However, if you experience digestive sensitivity, try a sublingual or liquid format.
Combine with a Healthy Lifestyle: Supplements work best when paired with a balanced diet rich in vitamin B3, regular exercise, and proper sleep. Foods like chicken, fish, nuts, and green vegetables naturally support NAD+ production.8
Adjust Gradually: If you’re new to NAD+ supplementation, start with a moderate dose to see how your body responds. You can gradually increase the dose over time based on energy levels and overall well-being.
Monitor Your Results: Consider using a health tracker or even simple blood tests (if available) to measure your NAD+ levels and assess how well the supplement is working for you.
Stay Informed: The field of NAD+ research is evolving rapidly. Keep up with new studies and reviews to ensure you’re always using the best formulation for your needs.
Final Thoughts: Is NAD+ Supplementation Right for You?
NAD+ supplementation offers a promising avenue to combat the cellular decline associated with aging. While robust human studies are still underway, the current evidence from both preclinical and short-term clinical trials indicates that boosting NAD+ levels can improve energy production, support DNA repair, and promote overall cellular health. Our top picks—from Renue By Science PURE NMN Powder for its versatility and budget-friendly pricing to ProHealth Longevity’s high-dose capsules for those needing a potent boost—provide a range of options to suit various lifestyles and health goals.
Remember that while these supplements can be a powerful tool in your anti-aging arsenal, they should complement a holistic approach to health. Prioritize a nutritious diet, regular exercise, and adequate sleep to maximize your overall wellness. And as always, consult with a healthcare professional before starting any new supplement regimen—especially if you have preexisting conditions or are taking other medications.
Our guide is designed to help you navigate the complex landscape of NAD+ supplements, providing you with the facts, expert insights, and real-world testing data you need to make the best choice for your long-term health and vitality.
How we reviewed this article:
Our experts vigilantly monitor the domain of health and wellness, promptly refreshing our articles with the latest discoveries. Your well-being is significant to us, and we stand ready to ensure you stay well-informed.
April 24, 2025
Current Version
April 24, 2025
April 24, 2025
Written By Grady Blacken, Ph.D. Edited By Suzanne Briggs Medically Reviewed By Dr Emma Thomas, MPH, PhD Copy Edited By David Lopez-Kopp
April 24, 2025
At Body Freedom, we rely solely on top-tier sources, such as peer-reviewed studies, to bolster the veracity of our content. Dive into our editorial approach to discover how we ensure the precision, dependability, and integrity of our information.
Arenas-Jal, M., Suñé-Negre, J. M., & García-Montoya, E. (2020). Therapeutic potential of nicotinamide adenine dinucleotide (NAD). European Journal of Pharmacology, 879, 173158. https://doi.org/10.1016/j.ejphar.2020.173158 ↩︎
Liu, K. K., Sun, W., Qin, Z. H., & Zhang, Z. L. (2025). The application of nicotinamide coenzymes and precursors. In Z. H. Qin (Ed.), Biology of nicotinamide coenzymes (pp. 757–776). Springer, Singapore. https://doi.org/10.1007/978-981-97-9877-3_46 ↩︎
Arenas-Jal, M., Suñé-Negre, J. M., & García-Montoya, E. (2020). Therapeutic potential of nicotinamide adenine dinucleotide (NAD). European Journal of Pharmacology, 879, 173158. https://doi.org/10.1016/j.ejphar.2020.173158 ↩︎
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022). Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nature Reviews Endocrinology, 18, 243–258. https://doi.org/10.1038/s41574-022-00606-2 ↩︎
She, J., Sheng, R., & Qin, Z.-H. (2021). Pharmacology and potential implications of nicotinamide adenine dinucleotide precursors. Aging and Disease, 12(8), 1879–1897. https://doi.org/10.14336/AD.2021.0523 ↩︎
Chini, C. S. C., Zeidler, J. D., Kashyap, S., Warner, G., & Nunes Chini, E. (2021). Evolving concepts in NAD(+) metabolism. Cell Metabolism, 33(6), 1076-1087. https://doi.org/10.1016/j.cmet.2021.04.003 ↩︎
Radenkovic, D., Reason, E., & Verdin, E. (2020). Clinical evidence for targeting NAD therapeutically. Pharmaceuticals, 13(9), 247. https://doi.org/10.3390/ph13090247 ↩︎
Sonawane, V. N., Surana, K. R., Ahire, E. D., Patil, D. M., & Sonawane, D. D. (2024). Vitamins as nutraceuticals for human nutrition. In Preventive and therapeutic role of vitamins as nutraceuticals (1st ed., pp. 22). Apple Academic Press. https://doi.org/10.1234/9781003414025 ↩︎
