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Premature Ejaculation Medicine: Treatment For Mens Sexual Condition

Premature Ejaculation Medicine


Last updated Fact Checked: Feb 9, 2022

What is the best treatment for men’s lifelong PE? Should you use ayurvedic remedies to cure this sexual dysfunction condition? Why use homeopathic pills and not medical doctor-prescribed drugs and medication?

Every day people are faced with problems, and so they resort to solutions that will give them the fastest and quickest resolution. So it is hardly surprising that many men are finding medication for primary premature ejaculation.

Pharmaceutical companies are making a killing off patients with such problems. Medication is usually highly-priced and is no exception when it comes to drugs for uncontrolled ejaculation.1

Even though Priligy pills are extremely expensive,2 I’m not just referring to them being a financial burden. Just as a side note Priligy, in some places in the world can cost up to a hundred dollars for a measly three pills.

But the primary concern is a far greater concern than price. The side effects of many medications for premature ejaculation are much larger than their benefits. Prescription medication is usually the one with the most adverse side effects3 because of its synthetic and unnatural nature.

Did you know that antidepressants are a common drug prescribed to people who have acquired premature ejaculation? Antidepressants may help you last longer but is it worth it when accompanying it comes erectile dysfunction and decreased libido.4

Now we’re not telling you that this stuff doesn’t work, what we’re saying is that if you read further, you will gain further insight into your best options. The pros should outweigh the cons.

And with various other methods with fewer side-effects and proven results why would anybody choose the former?

Let’s Talk About Antidepressants

Some of the common medications prescribed go by the brand names Paxil, Zoloft, Anafranil, and even Prozac.5

When I first found out that antidepressants were prescribed commonly to sufferers of rapid ejaculation I was surprised too. Even though they are not conventional treatments, family physicians still issue them regularly.6

Paroxetine (Paxil), Fluoxetine (Prozac), Sertraline (Zoloft/ Lustral) are the three main common ones, with the brand names in brackets.

They are often referred to as selective serotonin reuptake inhibitors (SSRIs for short). Naturally, when prescribed to sufferers of early ejaculation, they are given in smaller doses than what would be given to somebody suffering from depression or anxiety.7 After regular consumption, the effects can be seen within a week or two.

Clomipramine (Anafranil) works in a slightly different way. It is a tricyclic antidepressant and is prescribed when or if the SSRI didn’t provide significant results.8

Common Problems Faced With Antidepressants

The three top issues and concerns are as follows;

What Are Other More Specific Side-Effects Of Delayed Ejaculation Medication?

1. Headaches, migraines, and dizzy spells12

2. Loss of libido13

3. Erectile dysfunction14

4. Diarrhea and stomach problems15

5. Loss of appetite and fluctuation in weight gain and weight loss16

6. Insomnia

7. Vomiting and nausea17

8. Male sexual dysfunction18

And the list is not exhaustive, not even close. You probably get the gist though now. Nobody denies that antidepressants don’t delay ejaculation. But you are opening up the whole new can of worms of conceivable side-effects.

NOTE:

Do not buy any of the listed medications online or from any questionable sources. Firstly it’s illegal and secondly extremely dangerous. These are prescription medicines. If you are unsure, speak to your doctor, in fact with regards to these medications you should talk to your doctor anyway.

Dapoxetine (Branded As Priligy)

Initially, Priligy was under the umbrella of the SSRI family. Well then, it became a proper medication for premature ejaculation.19

Priligy is slightly different in its composition meaning that it is processed at a faster speed by the body than common SSRIs. The benefit of this is that you don’t have to take it daily, sufficient for you is to take it only on the days you plan to have sexual intercourse.20

Even though it has approval from around most of the globe, America is yet to approve of it.21

The FDA has not approved it; it is available on the NHS in certain regions in the Uk.

I did try it about a year ago, and it worked to some extent. It gave me an extra two or three minutes before ejaculating. So two or 3 minutes of extra sexual penetration with minimal sexual stimulation and two or three hours of having to deal with a migraine. Not the best of experiences as you can imagine.

That’s just me, though; clinical trials show that almost all men experience side effects even if they are minimal. So it doesn’t get my vote, it’s a bit expensive too. The cons outweigh the pros on this one.

 

What Other Sexual Medicine Is Out There Then?

Well, there is Tramadol, it is a synthesized opioid analgesic. It has been more recently discovered to delay orgasm.22

This is something I found out at random. It’s a funny story actually, a few years ago after undergoing surgery I was prescribed it, and it added about five minutes on average. That’s, not just me saying this but if you read some of the clinical studies they will confirm my claim.23

The downfall though is because it is an opioid it is very addictive.24 Your body will become dependent on it. So I highly doubt that it will ever get approved to be an accepted premature ejaculation treatment option.

If you are using it for pain relief, the dose will be higher. For premature ejaculation, 25 mg to 50 mg will be more than enough.25 As for pain-alleviation, the dose will be more like 400 mg.26

Owing to being relatively new in comparison to the previous ones mentioned, there was not enough evidence to suggest its safety. When you compare the side effects of the SSRIs discussed previously, you would see that they are much more severe,27 here is a list of a few of them:

Only take Tramadol if it is prescribed to you by a doctor. Avoid any online shops or dodgy places. Just something to keep in mind.

5 – HTP Supplements

Even though the primary cause for premature ejaculation remains a mystery in its completeness. Scientists and medical professionals have long believed that one of the principal reasons is a lack of low serotonin levels in the body.34 Consequently, supplementing yourself with 5 HTP can restore serotonin levels to the norm.35

It is important to note that there is no substantial evidence to support this, 5- HTP that is. The good thing is though that it is quickly picked up from any sexual health store, just like a regular supplement. You don’t need to splash out on a branded version, and it’s safe and needs no prescription.36

To achieve the same result more naturally, just try eating food high in tryptophan. Meat, eggs, and fish are examples of foods naturally high in tryptophan. Tryptophan is a precursor of serotonin.37

5-HTP is completely safe; it’s a natural supplement, and thus you will find that many natural ejaculation pills contain it as one of the key ingredients. It doesn’t require FDA approval as it is sold as a herbal supplement and not a medication.

Had Enough With The Side Effects Of These Premature Ejaculation Medications?

Don’t despair, in most cases; there is no need to resort to prescription medications for treating premature ejaculation. There are many natural and much safer alternatives available in the form of a pill. They contain natural herbs to delay ejaculation.

Not every pill is made equal.

The quality of ingredients, reputation of the company, price, and ethics of the manufacturers will result in the variable quality of the end product.

For a more natural, herbal based pill which we have thoroughly researched and confidently recommend, you should read our article on premature ejaculation pills.

Or why not try a desensitizing cream or spray.38 You don’t need to swallow anything; it is absorbed directly into the skin of your penis, and it works by numbing it to decrease sensation and therefore allowing you to last longer. Check out our recommendations in this article:

If money is a concern, the best thing to do would be to try natural pelvic floor exercises to strengthen the pelvic floor muscles to help improve your sexual experience by prolonging your sexual encounter.39 Some of these techniques are outlined for FREE in this video. If you can learn these techniques, you will be able to control your lifelong premature ejaculation problem without needing to resort to harmful medicine.

Sources

Body Freedom exclusively utilizes the best quality sources, including peer-reviewed studies, to support the facts in our content. Read our editorial process to learn more regarding our fact-checking to maintain the accuracy, reliability, and trustworthiness of our content.

  1. Park, Hyun Jun, et al. “Discontinuation of dapoxetine treatment in patients with premature ejaculation: a 2-year prospective observational study.Sexual Medicine 5.2 (2017): e99-e105.
  2. Marshania, Z., et al. “P-02-25 Treatment of Premature Ejaculation by Dapoxetine in Georgia: Pro Et Contra.The Journal of Sexual Medicine 17.6 (2020): S179.
  3. Jern, P., et al. “Antidepressant treatment of premature ejaculation: discontinuation rates and prevalence of side effects for dapoxetine and paroxetine in a naturalistic setting.International journal of impotence research 27.2 (2015): 75-80.
  4. Rothmore, Jody. “Antidepressant-induced sexual dysfunction.” The Medical journal of Australia vol. 212,7 (2020): 329-334. doi:10.5694/mja2.50522
  5. Cupp, Melanie Johns, and Timothy S. Tracy. “Cytochrome P450: new nomenclature and clinical implications.American family physician 57.1 (1998): 107.
  6. Van Geffen, Erica CG, et al. “The decision to continue or discontinue treatment: experiences and beliefs of users of selective serotonin-reuptake inhibitors in the initial months—a qualitative study.Research in Social and Administrative Pharmacy 7.2 (2011): 134-150.
  7. Montejo, Angel L., et al. “Management strategies for antidepressant-related sexual dysfunction: A clinical approach.Journal of clinical medicine 8.10 (2019): 1640.
  8. Kim, Sae Woong, et al. “Tolerability and adequate therapeutic dosage of oral clomipramine for the treatment of premature ejaculation: a randomized, double-blind, placebo-controlled, fixed-dose, parallel-grouped clinical study.International journal of impotence research 30.2 (2018): 65-70.
  9. Hengartner, Michael P., et al. “Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum.Therapeutic Advances in Psychopharmacology 10 (2020): 2045125320980573.
  10. Montejo, Angel L., et al. “Management strategies for antidepressant-related sexual dysfunction: A clinical approach.” Journal of clinical medicine 8.10 (2019): 1640.
  11. Spielmans, Glen I et al. “Duty to Warn: Antidepressant Black Box Suicidality Warning Is Empirically Justified.” Frontiers in psychiatry vol. 11 18. 13 Feb. 2020, doi:10.3389/fpsyt.2020.00018
  12. Gonda, Xenia et al. “Novel antidepressant drugs: Beyond monoamine targets.” CNS spectrums, 1-10. 30 Sep. 2021, doi:10.1017/S1092852921000791
  13. Healy, David. “Antidepressants and sexual dysfunction: a history.Journal of the Royal Society of Medicine 113.4 (2020): 133-135.
  14. Razdan, Shirin et al. “Effect of prescription medications on erectile dysfunction.” Postgraduate medical journal vol. 94,1109 (2018): 171-178. doi:10.1136/postgradmedj-2017-135233
  15. Jafferany, Mohammad et al. “Psychotropic drugs in dermatology: A dermatologist’s approach and choice of medications.” Dermatologic therapy vol. 33,3 (2020): e13385. doi:10.1111/dth.13385
  16. Wharton, Sean, et al. “Medications that cause weight gain and alternatives in Canada: a narrative review.Diabetes, metabolic syndrome and obesity: targets and therapy 11 (2018): 427.
  17. Schwasinger-Schmidt, T E, and M Macaluso. “Other Antidepressants.” Handbook of experimental pharmacology vol. 250 (2019): 325-355. doi:10.1007/164_2018_167
  18. Olivier, Jocelien DA, and Berend Olivier. “Antidepressants and Sexual Dysfunctions: a Translational Perspective.Current Sexual Health Reports 3 (2019): 156-166.
  19. Colonnello, Elena, et al. “Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity.Nature Reviews Urology 18.2 (2021): 115-127.
  20. Hellstrom, Wayne J G. “Emerging treatments for premature ejaculation: focus on dapoxetine.” Neuropsychiatric disease and treatment vol. 5 (2009): 37-46. doi:10.2147/ndt.s3251
  21. Osterloh, Ian H., et al. “Pharmacokinetics, Safety, and Tolerability of Single Oral Doses of a Novel Oxytocin Receptor Antagonist—Cligosiban—in Development for Premature Ejaculation: Three Randomized Clinical Trials in Healthy Subjects.The Journal of Sexual Medicine 15.11 (2018): 1547-1557.
  22. El Wasify, Mohamed, et al. “The Sociodemographic and Clinical Characteristics of Tramadol Dependence Among Egyptians and Their Relationship to the Associated Insomnia.Addictive Disorders & Their Treatment 17.2 (2018): 98-106.
  23. Sharma, Aditya Prakash et al. “Safety and efficacy of “on-demand” tramadol in patients with premature ejaculation: an updated meta-analysis.” International braz j urol : official journal of the Brazilian Society of Urology vol. 47,5 (2021): 921-934. doi:10.1590/S1677-5538.IBJU.2020.0561
  24. Edinoff AN, Kaplan LA, Khan S, et al. Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations. Anesth Pain Med. 2021;11(4):e119156. Published 2021 Sep 6. doi:10.5812/aapm.119156
  25. Kirby, E., Carson, C. & Coward, R. Tramadol for the management of premature ejaculation: a timely systematic review. Int J Impot Res 27, 121–127 (2015). https://doi.org/10.1038/ijir.2015.7
  26. Subedi, Muna, et al. “An overview of tramadol and its usage in pain management and future perspective.Biomedicine & Pharmacotherapy 111 (2019): 443-451.
  27. Hassamal, Sameer, et al. “Tramadol: understanding the risk of serotonin syndrome and seizures.The American journal of medicine 131.11 (2018): 1382-e1.
  28. O’Malley, Patricia Anne. “Think tramadol is a safer option? Think again!: prescribing considerations for the clinical nurse specialist.Clinical Nurse Specialist 33.5 (2019): 209-211.
  29. Kanbayashi, Y., et al. “Factors affecting the effect of naldemedine for opioid-induced constipation: a single-institution, retrospective analysis.Die Pharmazie-An International Journal of Pharmaceutical Sciences 76.4 (2021): 175-178.
  30. Mane, Robert Jonathon, Joanne Jung Eun Choi, and William Fox Sharpe-Davidson. “Tramadol as a local anaesthetic agent in dentistry: A systematic review of local and systemic adverse effects.The Saudi Dental Journal 33.8 (2021): 842-852.
  31. Memarian, Azadeh, Naimeh Farhidnia, and Fardin Fallahi. “Generalized tonic colonic seizure followed by loss of consciousness early after using low dose of tramadol: A case report.Anesthesiology and pain medicine 8.3 (2018).
  32. de Villa, Ariel Ruiz, et al. “Serotonin Toxicity Precipitated by Tramadol in the Setting of Polypharmacy: A Case of Serotonin Syndrome.Cureus 13.11 (2021).
  33. Jean, Yuel-Kai et al. “Tramadol-associated hallucinations: a systematic review and narrative synthesis of their pathophysiology, diagnosis, and treatment.” “Les hallucinations associées au tramadol : revue systématique et synthèse narrative de leur physiopathologie, leur diagnostic et leur traitement.” Canadian journal of anaesthesia = Journal canadien d’anesthesie vol. 67,3 (2020): 360-368. doi:10.1007/s12630-019-01548-9
  34. Raveendran, Arkiath Veettil, and Ankur Agarwal. “Premature ejaculation-current concepts in the management: A narrative review.International Journal of Reproductive Biomedicine 19.1 (2021): 5.
  35. Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22(1):181. Published 2020 Dec 26. doi:10.3390/ijms22010181
  36. Meloni, M et al. “Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson’s disease: a preliminary finding.” European journal of neurology vol. 27,5 (2020): 779-786. doi:10.1111/ene.14179
  37. Dhailappan, Arunkumar, and Sumathi Samiappan. “Impact of Diet on Neurotransmitters.Role of Nutrients in Neurological Disorders. Springer, Singapore, 2022. 363-383.
  38. Boeri, Luca, et al. “Real-life use of the eutectic mixture lidocaine/prilocaine spray in men with premature ejaculation.International journal of impotence research (2021): 1-6.
  39. Raveendran, Arkiath Veettil, and Ankur Agarwal. “Premature ejaculation-current concepts in the management: A narrative review.” International Journal of Reproductive Biomedicine 19.1 (2021): 5.

Shahrokh Shariat, MD

Prof. Shariat has published over 1400 scientific papers in peer-reviewed journals. In 2014 he received the Matula Award from the European Society of Urology (EAU), in 2017 the Gold Cystoscope Award from the American Society of Urology, probably the most important urologist award worldwide.

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